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Phosphorylated MAP kinase ERK2

Analyse Phosphorylated MAP kinase ERK2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ERK
Type: protein
Length: 353 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Extracellular signal-regulated kinase 2
EC: 2.7.1.-
UniProt: P63086
Pockets: 6 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Extracellular signal-regulated kinase 2 (EC 2.7.1.-)	protein	353	39% helix, 14% strand	P63086

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	369	0.65	0.79	42	empty
2	90	0.44	0.79	20	empty
3	76	0.36	0.77	17	empty
4	72	0.34	0.75	14	empty
5	54	0.29	0.75	12	empty

Modifications

Observed in the structure: 2 modified (phosphorylation).

Compared structures

2ERK · Phosphorylated MAP kinase ERK2 · the same entry in another collection · chain A against A, TM-score 1.00
P63086 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 1 (P63086) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63086
Elsewhere: RCSB PDB 2ERK · PDBe 2ERK · UniProt P63086

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