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Crystal structure of a deletion mutant of the type II beta regulatory subunit of camp-dependent protein kinase
Analyse Crystal structure of a deletion mutant of the type II beta regulatory subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CX4
- Type
- protein
- Length
- 275 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase regulatory subunit type II beta
- UniProt
- P12369
- Ligands
- CMP
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase regulatory subunit type II beta | protein | 275 | 37% helix, 33% strand | P12369 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.70 | 0.81 | 58 | CMP |
| 2 | 198 | 0.67 | 0.85 | 27 | CMP |
Compared structures
- 1CX4 · Crystal structure of a deletion mutant of the type II beta regulatory subunit of… · the same entry in another collection · chain A against A, TM-score 1.00
- P12369 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type II-beta… · a predicted model of the same protein · chain A against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12369
- Elsewhere: RCSB PDB 1CX4 · PDBe 1CX4 · UniProt P12369
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