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Crystal structure of the bar-pH domain of human APPL1

Analyse Crystal structure of the bar-pH domain of human APPL1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ELB
Type: protein
Length: 351 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adapter protein containing pH domain, ptb domain and leucine zipper motif 1
UniProt: Q9UKG1
Pockets: 1 · best druggability 0.28

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adapter protein containing pH domain, ptb domain and leucine zipper motif 1	protein	351	68% helix, 8% strand	Q9UKG1

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.28	0.73	16	empty

Modifications

Observed in the structure: 14 modified (engineered).

Compared structures

2ELB · Crystal Structure of the BAR-PH domain of human APPL1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9UKG1 · AlphaFold monomer V2.0 prediction for dcc-interacting protein 13-alpha (Q9UKG1) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UKG1
Elsewhere: RCSB PDB 2ELB · PDBe 2ELB · UniProt Q9UKG1

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