Research workbench
Crystal structure of humanized hyhel-10 fv MUTANT(HW47Y)-hen lysozyme complex
Analyse Crystal structure of humanized hyhel-10 fv MUTANT(HW47Y)-hen lysozyme complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2EIZ
- Type
- protein
- Length
- 349 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-lysozyme antibody fv region; Lysozyme C
- EC
- 3.2.1.17
- UniProt
- P00698
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anti-lysozyme antibody fv region | protein | 107 | 3% helix, 50% strand | — |
| B | Anti-lysozyme antibody fv region | protein | 113 | 11% helix, 49% strand | — |
| C | Lysozyme C (EC 3.2.1.17) | protein | 129 | 42% helix, 11% strand | P00698 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.64 | 0.84 | 30 | empty |
| 2 | 96 | 0.39 | 0.76 | 17 | empty |
| 3 | 56 | 0.27 | 0.73 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 705 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 545 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 440 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2EIZ · Crystal structure of humanized HYHEL-10 fv mutant(HW47Y)-hen lysozyme complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00698
- Elsewhere: RCSB PDB 2EIZ · PDBe 2EIZ · UniProt P00698
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