Research workbench
Crystal structure of a putative protein (AQ1627) from aquifex aeolicus
Analyse Crystal structure of a putative protein (AQ1627) from aquifex aeolicus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2EIU
- Type
- protein
- Length
- 733 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein AQ_1627
- UniProt
- O67549
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein AQ_1627 | protein | 115 | 37% helix, 21% strand | O67549 |
| C | Hypothetical protein AQ_1627 | protein | 120 | 36% helix, 21% strand | O67549 |
| D, G | Hypothetical protein AQ_1627 | protein | 124 | 35% helix, 20% strand | O67549 |
| E, F | Hypothetical protein AQ_1627 | protein | 125 | 34% helix, 20% strand | O67549 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 606 | 0.71 | 0.79 | 66 | empty |
| 2 | 555 | 0.65 | 0.76 | 58 | empty |
| 3 | 56 | 0.50 | 0.86 | 18 | empty |
| 4 | 52 | 0.36 | 0.79 | 14 | empty |
Interfaces
6 interfaces between chains.
- D–G · 1003 Ų buried · 4 hydrogen bonds · protein-protein
- C–E · 913 Ų buried · 6 hydrogen bonds · protein-protein
- A–F · 824 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 163 Ų buried · 0 hydrogen bonds · protein-protein
- C–G · 158 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2EIU · Crystal Structure of a Putative protein (AQ1627) from Aquifex aeolicus · the same entry in another collection · chain G against G, TM-score 1.00
- O67549 · AlphaFold monomer V2.0 prediction for uncharacterized protein AQ_1627 (O67549) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67549
- Elsewhere: RCSB PDB 2EIU · PDBe 2EIU · UniProt O67549
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.