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Crystal structure of the ligand-free form of the flavin reductase component (hpac) of 4-hydroxyphenylacetate 3-monooxygenase
Analyse Crystal structure of the ligand-free form of the flavin reductase component… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ECR
- Type
- protein
- Length
- 298 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Flavin reductase component (hpac) of 4-hydroxyphenylacetate 3-monooxygenase
- EC
- 1.6.8.-
- UniProt
- Q5SJP7
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 14% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Flavin reductase component (hpac) of 4-hydroxyphenylacetate 3-monooxygenase (EC 1.6.8.-) | protein | 149 | 14% helix, 46% strand | Q5SJP7 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 353 | 0.60 | 0.77 | 39 | empty |
| 2 | 311 | 0.58 | 0.77 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 2531 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 2ECR · Crystal structure of the ligand-free form of the flavin reductase component (HpaC) of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q5SJP7 · AlphaFold monomer V2.0 prediction for 4-hydroxyphenylacetate 3-monooxygenase, reductase… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SJP7
- Elsewhere: RCSB PDB 2ECR · PDBe 2ECR · UniProt Q5SJP7
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