Research workbench
Crystal structure of the stationary phase survival protein sure from thermus thermophilus HB8 in complex with phosphate
Analyse Crystal structure of the stationary phase survival protein sure from thermus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E6G
- Type
- protein
- Length
- 2,722 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-nucleotidase sure
- EC
- 3.1.3.5
- UniProt
- Q53W92
- Ligands
- PO4
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 12 distinct chains · 28% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 221 | 29% helix, 33% strand | Q53W92 |
| B | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 225 | 29% helix, 30% strand | Q53W92 |
| C | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 225 | 27% helix, 33% strand | Q53W92 |
| D | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 228 | 25% helix, 32% strand | Q53W92 |
| E | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 233 | 27% helix, 32% strand | Q53W92 |
| F | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 228 | 28% helix, 30% strand | Q53W92 |
| G | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 229 | 27% helix, 30% strand | Q53W92 |
| H | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 229 | 28% helix, 31% strand | Q53W92 |
| I | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 227 | 29% helix, 32% strand | Q53W92 |
| J | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 222 | 27% helix, 32% strand | Q53W92 |
| K | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 226 | 28% helix, 34% strand | Q53W92 |
| L | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 229 | 28% helix, 33% strand | Q53W92 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 25 copies · chains A, B, C, D, E, F, G, H, I, J, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 875 | 0.75 | 0.79 | 98 | PO4 |
| 2 | 981 | 0.74 | 0.77 | 75 | empty |
| 3 | 994 | 0.71 | 0.75 | 92 | empty |
| 4 | 574 | 0.71 | 0.79 | 71 | PO4 |
| 5 | 884 | 0.71 | 0.76 | 103 | PO4 |
Interfaces
24 interfaces between chains.
- C–D · 2958 Ų buried · 45 hydrogen bonds · protein-protein
- G–H · 2922 Ų buried · 37 hydrogen bonds · protein-protein
- K–L · 2900 Ų buried · 38 hydrogen bonds · protein-protein
- E–F · 2865 Ų buried · 36 hydrogen bonds · protein-protein
- A–B · 2782 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 2E6G · Crystal structure of the stationary phase survival protein SurE from Thermus thermophilus… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q53W92
- Elsewhere: RCSB PDB 2E6G · PDBe 2E6G · UniProt Q53W92
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