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Crystal structure of the stationary phase survival protein sure from thermus thermophilus HB8
Analyse Crystal structure of the stationary phase survival protein sure from thermus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E6E
- Type
- protein
- Length
- 853 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-nucleotidase sure
- EC
- 3.1.3.5
- UniProt
- Q53W92
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 4 distinct chains · 28% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 221 | 27% helix, 35% strand | Q53W92 |
| B | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 210 | 28% helix, 33% strand | Q53W92 |
| C | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 217 | 28% helix, 34% strand | Q53W92 |
| D | 5'-nucleotidase sure (EC 3.1.3.5) | protein | 205 | 29% helix, 32% strand | Q53W92 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 587 | 0.64 | 0.75 | 67 | empty |
| 2 | 535 | 0.63 | 0.75 | 53 | empty |
| 3 | 516 | 0.60 | 0.74 | 50 | empty |
| 4 | 179 | 0.48 | 0.76 | 24 | empty |
| 5 | 79 | 0.46 | 0.82 | 25 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2480 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 2441 Ų buried · 40 hydrogen bonds · protein-protein
- B–D · 755 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 498 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 474 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2E6E · Crystal structure of the stationary phase survival protein SurE from Thermus thermophilus… · the same entry in another collection · chain D against D, TM-score 1.00
- Q53W92 · AlphaFold monomer V2.0 prediction for 5'-nucleotidase sure (Q53W92) · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q53W92
- Elsewhere: RCSB PDB 2E6E · PDBe 2E6E · UniProt Q53W92
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