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Crystal structure of human nmprtase as free-form
Analyse Crystal structure of human nmprtase as free-form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E5B
- Type
- protein
- Length
- 932 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nicotinamide phosphoribosyltransferase
- EC
- 2.4.2.12
- UniProt
- P43490
- Pockets
- 7 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Nicotinamide phosphoribosyltransferase (EC 2.4.2.12) | protein | 466 | 41% helix, 19% strand | P43490 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 771 | 0.79 | 0.83 | 92 | empty |
| 2 | 722 | 0.78 | 0.82 | 86 | empty |
| 3 | 730 | 0.75 | 0.80 | 63 | empty |
| 4 | 51 | 0.32 | 0.78 | 17 | empty |
| 5 | 55 | 0.30 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 4327 Ų buried · 78 hydrogen bonds · protein-protein
Compared structures
- 2E5B · Crystal structure of Human NMPRTase as free-form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43490
- Elsewhere: RCSB PDB 2E5B · PDBe 2E5B · UniProt P43490
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