Research workbench
Crystal structure of E. COLI glucose-1-phosphate uridylyltransferase
Analyse Crystal structure of E. COLI glucose-1-phosphate uridylyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E3D
- Type
- protein
- Length
- 1,133 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- UTP--glucose-1-phosphate uridylyltransferase
- EC
- 2.7.7.9
- UniProt
- P0AEP3
- Pockets
- 14 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 286 | 38% helix, 22% strand | P0AEP3 |
| B | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 281 | 41% helix, 22% strand | P0AEP3 |
| C | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 288 | 38% helix, 21% strand | P0AEP3 |
| D | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 278 | 38% helix, 22% strand | P0AEP3 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 797 | 0.86 | 0.89 | 98 | empty |
| 2 | 265 | 0.63 | 0.81 | 26 | empty |
| 3 | 263 | 0.61 | 0.80 | 41 | empty |
| 4 | 289 | 0.57 | 0.77 | 36 | empty |
| 5 | 232 | 0.57 | 0.79 | 28 | empty |
Interfaces
6 interfaces between chains.
- A–C · 2258 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 2250 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 825 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 760 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 180 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2E3D · Crystal structure of E. coli glucose-1-phosphate uridylyltransferase · the same entry in another collection · chain D against D, TM-score 1.00
- P0AEP3 · AlphaFold monomer V2.0 prediction for UTP--glucose-1-phosphate uridylyltransferase… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEP3
- Elsewhere: RCSB PDB 2E3D · PDBe 2E3D · UniProt P0AEP3
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