Research workbench
Structure of putative hth-type transcriptional regulator PH1519/DNA complex
Analyse Structure of putative hth-type transcriptional regulator PH1519/DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E1C
- Type
- protein + DNA
- Length
- 181 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*DAP*DGP*DTP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DTP*DCP*DAP*DCP*DA )-3'); DNA…
- UniProt
- O59188
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'- D(*DAP*DGP*DTP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DTP*DCP*DAP*DCP*DA )-3') | dna | 17 | — | — |
| D | DNA (5'- D(*DTP*DGP*DTP*DGP*DAP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DAP*DCP*DT )-3') | dna | 17 | — | — |
| A | Putative hth-type transcriptional regulator PH1519 | protein | 147 | 40% helix, 20% strand | O59188 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.45 | 0.76 | 18 | empty |
| 2 | 145 | 0.45 | 0.76 | 17 | empty |
| 3 | 50 | 0.26 | 0.74 | 14 | empty |
Interfaces
3 interfaces between chains.
- B–D · 754 Ų buried · 49 hydrogen bonds · nucleic-nucleic
- D–A · 296 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–A · 275 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 2E1C · Structure of Putative HTH-type transcriptional regulator PH1519/DNA Complex · the same entry in another collection · chain B against B, TM-score 1.00
- O59188 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator FL11 (O59188) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59188
- Elsewhere: RCSB PDB 2E1C · PDBe 2E1C · UniProt O59188
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