Research workbench
T391A precursor mutant protein of gamma-glutamyltranspeptidase from escherichia COLI
Analyse T391A precursor mutant protein of gamma-glutamyltranspeptidase from escherichia… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E0W
- Type
- protein
- Length
- 996 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-glutamyltranspeptidase
- EC
- 2.3.2.2
- UniProt
- P18956
- Pockets
- 6 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma-glutamyltranspeptidase (EC 2.3.2.2) | protein | 496 | 39% helix, 19% strand | P18956 |
| B | Gamma-glutamyltranspeptidase (EC 2.3.2.2) | protein | 500 | 39% helix, 18% strand | P18956 |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 803 | 0.83 | 0.86 | 72 | empty |
| 2 | 303 | 0.76 | 0.88 | 46 | empty |
| 3 | 435 | 0.72 | 0.82 | 57 | empty |
| 4 | 176 | 0.58 | 0.82 | 34 | empty |
| 5 | 155 | 0.55 | 0.81 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 1284 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 2E0W · T391A precursor mutant protein of gamma-Glutamyltranspeptidase from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
- P18956 · AlphaFold monomer V2.0 prediction for glutathione hydrolase proenzyme (P18956) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18956
- Elsewhere: RCSB PDB 2E0W · PDBe 2E0W · UniProt P18956
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.