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Crystal structure of H369L mutant of yeast bleomycin hydrolase

Analyse Crystal structure of H369L mutant of yeast bleomycin hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2E02
Type: protein
Length: 443 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cysteine proteinase 1
EC: 3.4.22.40
UniProt: Q01532
Pockets: 6 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cysteine proteinase 1 (EC 3.4.22.40)	protein	443	44% helix, 17% strand	Q01532

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	187	0.70	0.87	31	empty
2	103	0.64	0.89	21	empty
3	240	0.49	0.74	35	empty
4	139	0.49	0.78	21	empty
5	141	0.43	0.75	21	empty

Compared structures

2E02 · Crystal structure of H369L mutant of yeast bleomycin hydrolase · the same entry in another collection · chain A against A, TM-score 1.00
Q01532 · AlphaFold monomer V2.0 prediction for cysteine proteinase 1, mitochondrial (Q01532) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q01532
Elsewhere: RCSB PDB 2E02 · PDBe 2E02 · UniProt Q01532

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