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Crystal structure of N392L mutant of yeast bleomycin hydrolase
Analyse Crystal structure of N392L mutant of yeast bleomycin hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E00
- Type
- protein
- Length
- 457 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine proteinase 1
- EC
- 3.4.22.40
- UniProt
- Q01532
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine proteinase 1 (EC 3.4.22.40) | protein | 457 | 43% helix, 18% strand | Q01532 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.66 | 0.86 | 31 | empty |
| 2 | 124 | 0.48 | 0.79 | 22 | empty |
| 3 | 51 | 0.43 | 0.83 | 17 | empty |
| 4 | 132 | 0.43 | 0.75 | 20 | empty |
| 5 | 50 | 0.27 | 0.74 | 14 | empty |
Compared structures
- 2E00 · Crystal structure of N392L mutant of yeast bleomycin hydrolase · the same entry in another collection · chain A against A, TM-score 1.00
- Q01532 · AlphaFold monomer V2.0 prediction for cysteine proteinase 1, mitochondrial (Q01532) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01532
- Elsewhere: RCSB PDB 2E00 · PDBe 2E00 · UniProt Q01532
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