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Crystal structure of N392V mutant of yeast bleomycin hydrolase

Analyse Crystal structure of N392V mutant of yeast bleomycin hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2DZZ
Type: protein
Length: 447 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cysteine proteinase 1
EC: 3.4.22.40
UniProt: Q01532
Pockets: 6 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cysteine proteinase 1 (EC 3.4.22.40)	protein	447	45% helix, 17% strand	Q01532

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	275	0.68	0.83	32	empty
2	109	0.63	0.88	23	empty
3	157	0.52	0.79	31	empty
4	143	0.48	0.78	20	empty
5	149	0.45	0.76	21	empty

Compared structures

2DZZ · Crystal structure of N392V mutant of yeast bleomycin hydrolase · the same entry in another collection · chain A against A, TM-score 1.00
Q01532 · AlphaFold monomer V2.0 prediction for cysteine proteinase 1, mitochondrial (Q01532) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q01532
Elsewhere: RCSB PDB 2DZZ · PDBe 2DZZ · UniProt Q01532

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