Research workbench

Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)

Analyse Crystal structure of human mitogen-activated protein kinase kinase 7 activated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2DYL
Type: protein
Length: 272 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dual specificity mitogen-activated protein kinase kinase 7
EC: 2.7.12.2
UniProt: O14733
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2)	protein	272	42% helix, 17% strand	O14733

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	202	0.55	0.79	20	empty
2	70	0.36	0.76	19	empty
3	76	0.32	0.74	15	empty
4	61	0.27	0.73	21	empty

Compared structures

2DYL · Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant… · the same entry in another collection · chain A against A, TM-score 1.00
O14733 · AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14733
Elsewhere: RCSB PDB 2DYL · PDBe 2DYL · UniProt O14733

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.