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Crystal structure of rhogef protein asef

Analyse Crystal structure of rhogef protein asef in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2DX1
Type: protein
Length: 385 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rho guanine nucleotide exchange factor 4
UniProt: Q9NR80
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rho guanine nucleotide exchange factor 4	protein	385	52% helix, 19% strand	Q9NR80

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	515	0.71	0.81	38	empty
2	520	0.64	0.76	50	empty
3	97	0.40	0.77	18	empty
4	93	0.39	0.76	21	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

2DX1 · Crystal structure of RhoGEF protein Asef · the same entry in another collection · chain A against A, TM-score 1.00
Q9NR80 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 4 (Q9NR80) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NR80
Elsewhere: RCSB PDB 2DX1 · PDBe 2DX1 · UniProt Q9NR80

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