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NMR structure of the C-terminal domain of the ligand-binding region of murine granulocyte colony-stimulating factor receptor, minimized average structure

Analyse NMR structure of the C-terminal domain of the ligand-binding region of murine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CTO
Type: protein
Length: 109 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Granulocyte colony-stimulating factor receptor
UniProt: P40223
Pockets: 2 · best druggability 0.48

Structure

solution nmr · 1 distinct chain · 0% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Granulocyte colony-stimulating factor receptor	protein	109	0% helix, 39% strand	P40223

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.48	0.82	24	empty
2	155	0.46	0.76	24	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1CTO · NMR structure of the C-terminal domain of the ligand-binding region of murine granulocyte… · the same entry in another collection · chain A against A, TM-score 1.00
P40223 · AlphaFold monomer V2.0 prediction for granulocyte colony-stimulating factor receptor… · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40223
Elsewhere: RCSB PDB 1CTO · PDBe 1CTO · UniProt P40223

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