Research workbench

Acanthamoeba myosin I SH3 domain bound to ACAN125

Analyse Acanthamoeba myosin I SH3 domain bound to ACAN125 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2DRK
Type: protein
Length: 69 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin heavy chain ib; 10-mer peptide from myosin-I binding protein ACAN125
UniProt: P19706, P90630
Ligands: SO4

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin heavy chain ib	protein	59	5% helix, 46% strand	P19706
B	10-mer peptide from myosin-I binding protein ACAN125	protein	10	0% helix, 0% strand	P90630

Ligands and binding sites

SO4 · Sulfate ion · ion · chains B
GOL · Glycerol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 485 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2DRK · Acanthamoeba myosin I SH3 domain bound to Acan125 · the same entry in another collection · chain A against A, TM-score 1.00
P19706 · AlphaFold monomer V2.0 prediction for myosin heavy chain ib (P19706) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19706
Every structure of UniProt P90630
Elsewhere: RCSB PDB 2DRK · PDBe 2DRK · UniProt P19706 · UniProt P90630

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