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Solution structure of the first zf-parp domain of human POLY(ADP- RIBOSE)POLYMERASE-1

Analyse Solution structure of the first zf-parp domain of human POLY(ADP… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2DMJ
Type: protein
Length: 106 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Poly (ADP-ribose) polymerase family, member 1
EC: 2.4.2.30
Ligands: ZN
Pockets: 1 · best druggability 0.28

Structure

solution nmr · 1 distinct chain · 16% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Poly (ADP-ribose) polymerase family, member 1 (EC 2.4.2.30)	protein	106	16% helix, 24% strand	—

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.28	0.75	13	empty

Compared structures

2DMJ · Solution structure of the first zf-PARP domain of human Poly(ADP-ribose)polymerase-1 · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2DMJ · PDBe 2DMJ

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