Research workbench
The crystal structure of allosteric chorismate mutase at 2.2 ångströms resolution
Analyse The crystal structure of allosteric chorismate mutase at 2.2 ångströms… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CSM
- Type
- protein
- Length
- 504 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chorismate mutase
- UniProt
- P32178
- Ligands
- TRP
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 62% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chorismate mutase | protein | 252 | 62% helix, 0% strand | P32178 |
Ligands and binding sites
- TRP · Tryptophan · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1013 | 0.86 | 0.87 | 106 | TRP |
| 2 | 206 | 0.70 | 0.87 | 23 | empty |
| 3 | 263 | 0.69 | 0.84 | 26 | empty |
| 4 | 132 | 0.46 | 0.77 | 22 | empty |
| 5 | 118 | 0.43 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1972 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1CSM · The crystal structure of allosteric chorismate mutase at 2.2 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
- P32178 · AlphaFold monomer V2.0 prediction for chorismate mutase (P32178) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32178
- Elsewhere: RCSB PDB 1CSM · PDBe 1CSM · UniProt P32178
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