Research workbench
Crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii STRAIN7
Analyse Crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii STRAIN7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2DHT
- Type
- protein
- Length
- 806 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 409AA long hypothetical NADP-dependent isocitrate dehydrogenase
- EC
- 1.1.1.42
- Pockets
- 8 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 409AA long hypothetical NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) | protein | 403 | 43% helix, 19% strand | — |
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.65 | 0.87 | 28 | empty |
| 2 | 406 | 0.59 | 0.76 | 39 | empty |
| 3 | 312 | 0.55 | 0.75 | 38 | empty |
| 4 | 333 | 0.55 | 0.76 | 37 | empty |
| 5 | 89 | 0.52 | 0.84 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 2746 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 2DHT · Crystal structure of isocitrate dehydrogenase from Sulfolobus tokodaii strain7 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2DHT · PDBe 2DHT
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