Research workbench
Whole cytosolic region of ATP-dependent metalloprotease ftsh (G399L)
Analyse Whole cytosolic region of ATP-dependent metalloprotease ftsh (G399L) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2DHR
- Type
- protein
- Length
- 2,715 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ftsh
- UniProt
- Q9LCZ4
- Ligands
- ADP
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 48% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Ftsh | protein | 458 | 46% helix, 7% strand | Q9LCZ4 |
| B | Ftsh | protein | 446 | 49% helix, 7% strand | Q9LCZ4 |
| D | Ftsh | protein | 445 | 49% helix, 7% strand | Q9LCZ4 |
| F | Ftsh | protein | 450 | 49% helix, 7% strand | Q9LCZ4 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 881 | 0.86 | 0.88 | 102 | empty |
| 2 | 901 | 0.86 | 0.88 | 96 | empty |
| 3 | 521 | 0.82 | 0.89 | 59 | empty |
| 4 | 872 | 0.82 | 0.84 | 92 | empty |
| 5 | 833 | 0.82 | 0.85 | 82 | empty |
Interfaces
9 interfaces between chains.
- D–E · 2523 Ų buried · 28 hydrogen bonds · protein-protein
- A–F · 2514 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 2501 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 1698 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 1609 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 2DHR · Whole cytosolic region of ATP-dependent metalloprotease FtsH (G399L) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9LCZ4
- Elsewhere: RCSB PDB 2DHR · PDBe 2DHR · UniProt Q9LCZ4
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