Research workbench
Foot and mouth disease virus RNA-dependent RNA polymerase in complex with vpg protein
Analyse Foot and mouth disease virus RNA-dependent RNA polymerase in complex with vpg… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2D7S
- Type
- protein
- Length
- 489 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-dependent RNA polymerase; VPG1 protein
- EC
- 2.7.7.48
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-dependent RNA polymerase (EC 2.7.7.48) | protein | 474 | 40% helix, 14% strand | — |
| B | VPG1 protein (EC 2.7.7.48) | protein | 15 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 998 | 0.83 | 0.84 | 94 | empty |
| 2 | 413 | 0.68 | 0.80 | 47 | empty |
| 3 | 55 | 0.29 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 975 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2D7S · Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with VPg protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2D7S · PDBe 2D7S
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