Research workbench
Pentaketide chromone synthase (M207G mutant)
Analyse Pentaketide chromone synthase (M207G mutant) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2D51
- Type
- protein
- Length
- 800 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pentaketide chromone synthase
- UniProt
- Q58VP7
- Pockets
- 10 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pentaketide chromone synthase | protein | 405 | 40% helix, 23% strand | Q58VP7 |
| B | Pentaketide chromone synthase | protein | 395 | 42% helix, 24% strand | Q58VP7 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.78 | 0.98 | 25 | empty |
| 2 | 108 | 0.78 | 0.98 | 24 | empty |
| 3 | 230 | 0.63 | 0.82 | 28 | empty |
| 4 | 261 | 0.61 | 0.80 | 30 | empty |
| 5 | 235 | 0.60 | 0.80 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 3487 Ų buried · 77 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58VP7
- Elsewhere: RCSB PDB 2D51 · PDBe 2D51 · UniProt Q58VP7
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