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NMR structure of the wif domain from human wif-1

Analyse NMR structure of the wif domain from human wif-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2D3J
Type: protein
Length: 157 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wnt inhibitory factor-1
UniProt: Q9Y5W5
Pockets: 1 · best druggability 0.79

Structure

solution nmr · 1 distinct chain · 9% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wnt inhibitory factor-1	protein	157	9% helix, 40% strand	Q9Y5W5

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.79	0.98	25	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2D3J · NMR structure of the WIF domain from human WIF-1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y5W5 · AlphaFold monomer V2.0 prediction for wnt inhibitory factor 1 (Q9Y5W5) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y5W5
Elsewhere: RCSB PDB 2D3J · PDBe 2D3J · UniProt Q9Y5W5

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