Research workbench
Crystal structure of the C-terminal SH3 domain of the adaptor protein gads in complex with slp-76 motif peptide reveals a unique SH3-SH3 interaction
Analyse Crystal structure of the C-terminal SH3 domain of the adaptor protein gads in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2D0N
- Type
- protein
- Length
- 133 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GRB2-related adaptor protein 2; Slp-76 binding peptide
- UniProt
- O89100
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GRB2-related adaptor protein 2 | protein | 59 | 5% helix, 47% strand | O89100 |
| B, D | Slp-76 binding peptide | protein | 9 | 33% helix, 0% strand | — |
| C | GRB2-related adaptor protein 2 | protein | 56 | 5% helix, 46% strand | O89100 |
Interfaces
5 interfaces between chains.
- A–C · 514 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 475 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 421 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 89 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 82 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2D0N · Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- O89100 · AlphaFold monomer V2.0 prediction for GRB2-related adaptor protein 2 (O89100) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O89100
- Elsewhere: RCSB PDB 2D0N · PDBe 2D0N · UniProt O89100
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