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Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-2 crystal)
Analyse Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CZ3
- Type
- protein
- Length
- 389 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maleylacetoacetate isomerase
- EC
- 5.2.1.2, 2.5.1.18
- UniProt
- Q9WVL0
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maleylacetoacetate isomerase (EC 5.2.1.2, 2.5.1.18) | protein | 191 | 54% helix, 9% strand | Q9WVL0 |
| B | Maleylacetoacetate isomerase (EC 5.2.1.2, 2.5.1.18) | protein | 198 | 53% helix, 9% strand | Q9WVL0 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 512 | 0.67 | 0.78 | 43 | empty |
| 2 | 441 | 0.66 | 0.79 | 44 | empty |
| 3 | 111 | 0.48 | 0.80 | 21 | empty |
| 4 | 109 | 0.47 | 0.80 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1403 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
- 2CZ3 · Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WVL0 · AlphaFold monomer V2.0 prediction for maleylacetoacetate isomerase (Q9WVL0) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WVL0
- Elsewhere: RCSB PDB 2CZ3 · PDBe 2CZ3 · UniProt Q9WVL0
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