Research workbench
Crystal structure of TTHA0137 from thermus thermophilus HB8
Analyse Crystal structure of TTHA0137 from thermus thermophilus HB8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CVL
- Type
- protein
- Length
- 744 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein translation initiation inhibitor
- UniProt
- Q5SM06
- Pockets
- 7 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Protein translation initiation inhibitor | protein | 124 | 31% helix, 31% strand | Q5SM06 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.81 | 0.97 | 48 | empty |
| 2 | 152 | 0.81 | 0.97 | 48 | empty |
| 3 | 1074 | 0.78 | 0.80 | 96 | empty |
| 4 | 202 | 0.63 | 0.83 | 29 | empty |
| 5 | 208 | 0.62 | 0.82 | 32 | empty |
Interfaces
9 interfaces between chains.
- D–F · 992 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 987 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 968 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 964 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 934 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 2CVL · Crystal structure of TTHA0137 from Thermus Thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SM06
- Elsewhere: RCSB PDB 2CVL · PDBe 2CVL · UniProt Q5SM06
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.