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Crystal structure of PH0766 from pyrococcus horikoshii OT3

Analyse Crystal structure of PH0766 from pyrococcus horikoshii OT3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2CSU
Type: protein
Length: 869 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 457AA long hypothetical protein
UniProt: O58493
Pockets: 7 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	457AA long hypothetical protein	protein	435	39% helix, 20% strand	O58493
B	457AA long hypothetical protein	protein	434	42% helix, 19% strand	O58493

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	244	0.81	0.94	42	empty
2	773	0.72	0.77	88	empty
3	654	0.70	0.78	67	empty
4	285	0.61	0.79	38	empty
5	117	0.49	0.80	20	empty

Interfaces

1 interface between chains.

A–B · 2039 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 30 modified (engineered).

Compared structures

2CSU · Crystal structure of PH0766 from Pyrococcus horikoshii OT3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O58493
Elsewhere: RCSB PDB 2CSU · PDBe 2CSU · UniProt O58493

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