Research workbench
Anti-anti-idiotypic antibody against human angiotensin II, complex with a synthetic cyclic peptide
Analyse Anti-anti-idiotypic antibody against human angiotensin II, complex with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CK0
- Type
- protein
- Length
- 438 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (immunoglobulin; Protein (11-mer
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Protein (immunoglobulin | protein | 216 | 6% helix, 52% strand | — |
| H | Protein (immunoglobulin | protein | 211 | 7% helix, 53% strand | — |
| P | Protein (11-mer | protein | 11 | 0% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 423 | 0.57 | 0.74 | 53 | empty |
| 2 | 56 | 0.54 | 0.89 | 19 | empty |
| 3 | 121 | 0.40 | 0.75 | 25 | empty |
| 4 | 79 | 0.35 | 0.76 | 17 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1627 Ų buried · 13 hydrogen bonds · protein-protein
- H–P · 391 Ų buried · 10 hydrogen bonds · protein-protein
- L–P · 201 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2CK0 · Anti-anti-idiotypic antibody against human angiotensin II, complex with a synthetic… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2CK0 · PDBe 2CK0
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