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Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal differences with plant enzymes

Analyse Crystal structure and enzymatic properties of a bacterial family 19 chitinase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2CJL
Type: protein
Length: 408 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Secreted chitinase
EC: 3.2.1.14
UniProt: Q8CK55
Ligands: ZN
Pockets: 2 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Secreted chitinase (EC 3.2.1.14)	protein	204	50% helix, 1% strand	Q8CK55

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.44	0.75	23	empty
2	131	0.42	0.75	23	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2CJL · Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CK55
Elsewhere: RCSB PDB 2CJL · PDBe 2CJL · UniProt Q8CK55

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