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Structure of RV3472(D26N), a function unknown protein from mycobacterium tuberculosis

Analyse Structure of RV3472(D26N), a function unknown protein from mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2CHC
Type: protein
Length: 489 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein RV3472
UniProt: O06337
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 3 distinct chains · 37% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein RV3472	protein	169	37% helix, 40% strand	O06337
B	Protein RV3472	protein	161	37% helix, 42% strand	O06337
C	Protein RV3472	protein	159	36% helix, 43% strand	O06337

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	462	0.79	0.86	63	empty
2	171	0.70	0.88	29	empty
3	270	0.69	0.84	35	empty
4	175	0.69	0.88	30	empty
5	136	0.56	0.82	32	empty

Interfaces

3 interfaces between chains.

A–B · 1184 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 1181 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 1110 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2CHC · Structure of Rv3472(D26N), a function unknown protein from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O06337
Elsewhere: RCSB PDB 2CHC · PDBe 2CHC · UniProt O06337

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