Research workbench
Crystal structure of an HSP90-SBA1 closed chaperone complex
Analyse Crystal structure of an HSP90-SBA1 closed chaperone complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CGE
- Type
- protein
- Length
- 1,215 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent molecular chaperone HSP82
- UniProt
- P02829
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | ATP-dependent molecular chaperone HSP82 | protein | 405 | 44% helix, 15% strand | P02829 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 922 | 0.79 | 0.82 | 96 | empty |
| 2 | 468 | 0.71 | 0.81 | 51 | empty |
| 3 | 215 | 0.57 | 0.79 | 31 | empty |
| 4 | 207 | 0.56 | 0.79 | 30 | empty |
| 5 | 188 | 0.55 | 0.79 | 35 | empty |
Interfaces
3 interfaces between chains.
- A–D · 664 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 636 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 610 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2CGE · Crystal structure of an Hsp90-Sba1 closed chaperone complex · the same entry in another collection · chain A against A, TM-score 1.00
- P02829 · AlphaFold monomer V2.0 prediction for ATP-dependent molecular chaperone HSP82 (P02829) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02829
- Elsewhere: RCSB PDB 2CGE · PDBe 2CGE · UniProt P02829
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