Research workbench
Architecture of mammalian fatty acid synthase
Analyse Architecture of mammalian fatty acid synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CF2
- Type
- protein
- Length
- 3,146 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid synthase, ks domain; Fatty acid synthase, mat domain; Fatty acid synthase, dh…
- EC
- 2.3.1.85
- Pockets
- 20 · best druggability 0.69
Structure
x-ray diffraction · 5 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, J | Fatty acid synthase, ks domain (EC 2.3.1.85) | protein | 406 | 0% helix, 0% strand | — |
| B, K | Fatty acid synthase, mat domain (EC 2.3.1.85) | protein | 304 | 0% helix, 0% strand | — |
| C, L | Fatty acid synthase, dh domain (EC 2.3.1.85) | protein | 342 | 0% helix, 0% strand | — |
| D, M | Fatty acid synthase, er domain (EC 2.3.1.85) | protein | 295 | 0% helix, 0% strand | — |
| E, N | Fatty acid synthase, kr domain (EC 2.3.1.85) | protein | 226 | 0% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 541 | 0.69 | 0.77 | 120 | empty |
| 2 | 625 | 0.66 | 0.74 | 117 | empty |
| 3 | 556 | 0.64 | 0.73 | 108 | empty |
| 4 | 496 | 0.62 | 0.73 | 97 | empty |
| 5 | 214 | 0.50 | 0.73 | 57 | empty |
Interfaces
13 interfaces between chains.
- C–L · 625 Ų buried · 0 hydrogen bonds · protein-protein
- A–J · 488 Ų buried · 0 hydrogen bonds · protein-protein
- J–L · 361 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 288 Ų buried · 0 hydrogen bonds · protein-protein
- A–L · 247 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2CF2 · Architecture of mammalian fatty acid synthase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2CF2 · PDBe 2CF2
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