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An EH1 peptide bound to the groucho-tle WD40 domain.

Analyse An EH1 peptide bound to the groucho-tle WD40 domain. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2CE8
Type: protein
Length: 1,366 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transducin-like enhancer protein 1; EH1 peptide
UniProt: Q04724
Pockets: 14 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 1% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transducin-like enhancer protein 1	protein	337	0% helix, 54% strand	Q04724
X, Y	EH1 peptide	protein	9	56% helix, 0% strand	—

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	671	0.80	0.84	66	empty
2	612	0.79	0.84	54	empty
3	649	0.79	0.84	55	empty
4	667	0.78	0.83	53	empty
5	57	0.58	0.91	15	empty

Interfaces

4 interfaces between chains.

A–B · 1171 Å² buried · 33 hydrogen bonds · protein-protein
C–D · 1171 Å² buried · 30 hydrogen bonds · protein-protein
A–X · 521 Å² buried · 8 hydrogen bonds · protein-protein
C–Y · 518 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2CE8 · An EH1 peptide bound to the Groucho-TLE WD40 domain. · the same entry in another collection · chain C against C, TM-score 1.00
Q04724 · AlphaFold monomer V2.0 prediction for transducin-like enhancer protein 1 (Q04724) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04724
Elsewhere: RCSB PDB 2CE8 · PDBe 2CE8 · UniProt Q04724

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