Research workbench
Architecture of the thermomyces lanuginosus fungal fatty acid synthase at 5 ångström resolution.
Analyse Architecture of the thermomyces lanuginosus fungal fatty acid synthase at 5… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CDH
- Type
- protein
- Length
- 10,404 residues
- Chains
- 36
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enoyl reductase; Acetyl transferase; Ketoacyl synthase; Ketoacyl reductase; Dehydratase
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 5 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 0, 1, 2, 3, Y, Z | Enoyl reductase | protein | 226 | 0% helix, 0% strand | — |
| 4, 5, 6, 7, 8, 9, M, N, O, P, Q, R | Acetyl transferase | protein | 305 | 0% helix, 0% strand | — |
| A, B, C, D, E, F | Ketoacyl synthase | protein | 406 | 0% helix, 0% strand | — |
| G, H, I, J, K, L | Ketoacyl reductase | protein | 244 | 0% helix, 0% strand | — |
| S, T, U, V, W, X | Dehydratase | protein | 248 | 0% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 746 | 0.74 | 0.77 | 145 | empty |
| 2 | 541 | 0.71 | 0.78 | 122 | empty |
| 3 | 365 | 0.64 | 0.77 | 77 | empty |
| 4 | 186 | 0.54 | 0.77 | 43 | empty |
| 5 | 236 | 0.52 | 0.74 | 37 | empty |
Interfaces
18 interfaces between chains.
- C–D · 1276 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 857 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 556 Ų buried · 0 hydrogen bonds · protein-protein
- 5–T · 173 Ų buried · 0 hydrogen bonds · protein-protein
- 9–X · 162 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2CDH · Architecture of the thermomyces lanuginosus fungal fatty acid synthase at 5 ångström… · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2CDH · PDBe 2CDH
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