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Cellular retinoic acid binding protein II in complex with a synthetic retinoic acid (ro-13 6307)

Analyse Cellular retinoic acid binding protein II in complex with a synthetic retinoic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2CBS
Type: protein
Length: 137 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (crabp-II)
UniProt: P29373
Ligands: R13
Pockets: 1 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (crabp-II)	protein	137	13% helix, 55% strand	P29373

Ligands and binding sites

R13 · 3-methyl-7-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl) -octa-2,4,6-trienoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	326	0.77	0.88	41	R13

Compared structures

2CBS · Cellular retinoic acid binding protein II in complex with a synthetic retinoic acid… · the same entry in another collection · chain A against A, TM-score 1.00
P29373 · AlphaFold monomer V2.0 prediction for cellular retinoic acid-binding protein 2 (P29373) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29373
Elsewhere: RCSB PDB 2CBS · PDBe 2CBS · UniProt P29373

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