Research workbench
Crystal structure of the catalytic domain of the mosquitocidal toxin from bacillus sphaericus, mutant E195Q
Analyse Crystal structure of the catalytic domain of the mosquitocidal toxin from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CB6
- Type
- protein
- Length
- 3,833 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mosquitocidal toxin
- UniProt
- Q03988
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 23% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E, F, I, J, M, N | Mosquitocidal toxin | protein | 238 | 21% helix, 24% strand | Q03988 |
| C, D, K, P | Mosquitocidal toxin | protein | 244 | 23% helix, 23% strand | Q03988 |
| G, L, O | Mosquitocidal toxin | protein | 236 | 25% helix, 24% strand | Q03988 |
| H | Mosquitocidal toxin | protein | 245 | 23% helix, 23% strand | Q03988 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 636 | 0.76 | 0.82 | 68 | empty |
| 2 | 1171 | 0.74 | 0.77 | 124 | empty |
| 3 | 647 | 0.73 | 0.80 | 66 | empty |
| 4 | 531 | 0.72 | 0.81 | 53 | empty |
| 5 | 569 | 0.72 | 0.80 | 48 | empty |
Interfaces
28 interfaces between chains.
- J–L · 787 Ų buried · 6 hydrogen bonds · protein-protein
- M–O · 785 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 767 Ų buried · 8 hydrogen bonds · protein-protein
- E–H · 765 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 748 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2CB6 · Crystal structure of the catalytic domain of the mosquitocidal toxin from Bacillus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03988
- Elsewhere: RCSB PDB 2CB6 · PDBe 2CB6 · UniProt Q03988
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.