Research workbench
Structural basis of the nucleotide driven conformational changes in the aaa domain of transcription activator pspf
Analyse Structural basis of the nucleotide driven conformational changes in the aaa… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2C99
- Type
- protein
- Length
- 243 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Psp operon transcriptional activator
- UniProt
- P37344
- Ligands
- ANP
- Pockets
- 3 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Psp operon transcriptional activator | protein | 243 | 47% helix, 13% strand | P37344 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.44 | 0.77 | 21 | ANP |
| 2 | 68 | 0.39 | 0.79 | 15 | empty |
| 3 | 89 | 0.37 | 0.76 | 17 | empty |
Compared structures
- 2C99 · Structural basis of the nucleotide driven conformational changes in the AAA domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P37344 · AlphaFold monomer V2.0 prediction for psp operon transcriptional activator (P37344) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37344
- Elsewhere: RCSB PDB 2C99 · PDBe 2C99 · UniProt P37344
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