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The structure of calcyclin reveals a novel homodimeric fold for S100 CA2+-binding proteins, NMR, 22 structures

Analyse The structure of calcyclin reveals a novel homodimeric fold for S100… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CNP
Type: protein
Length: 180 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcyclin (rabbit, apo)
UniProt: P30801
Pockets: 2 · best druggability 0.72

Structure

solution nmr · 1 distinct chain · 58% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Calcyclin (rabbit, apo)	protein	90	58% helix, 0% strand	P30801

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	351	0.72	0.84	41	empty
2	56	0.30	0.75	11	empty

Interfaces

1 interface between chains.

A–B · 1040 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1CNP · The structure of calcyclin reveals a novel homodimeric fold for S100 CA2+-binding… · the same entry in another collection · chain A against A, TM-score 1.00
P30801 · AlphaFold monomer V2.0 prediction for protein S100-A6 (P30801) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30801
Elsewhere: RCSB PDB 1CNP · PDBe 1CNP · UniProt P30801

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