Research workbench
MS2-RNA hairpin (2ONE -5) complex
Analyse MS2-RNA hairpin (2ONE -5) complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2C4Q
- Type
- protein + RNA
- Length
- 421 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coat protein; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *PYO*AP*CP*CP*CP*AP*UP*GP*U)-3'
- UniProt
- P03612
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 19% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Coat protein | protein | 129 | 19% helix, 46% strand | P03612 |
| R, S | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *PYO*AP*CP*CP*CP*AP*UP*GP*U)-3' | rna | 17 | — | — |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 492 | 0.71 | 0.81 | 42 | empty |
| 2 | 475 | 0.63 | 0.76 | 49 | empty |
| 3 | 393 | 0.61 | 0.77 | 40 | empty |
| 4 | 338 | 0.50 | 0.73 | 22 | empty |
| 5 | 76 | 0.31 | 0.74 | 16 | empty |
Interfaces
6 interfaces between chains.
- A–B · 3336 Ų buried · 44 hydrogen bonds · protein-protein
- A–C · 524 Ų buried · 5 hydrogen bonds · protein-protein
- C–S · 472 Ų buried · 11 hydrogen bonds · protein-nucleic
- B–R · 454 Ų buried · 15 hydrogen bonds · protein-nucleic
- A–R · 425 Ų buried · 12 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 modified (nucleotide modification).
Compared structures
- 2C4Q · MS2-RNA hairpin (2ONE -5) complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03612
- Elsewhere: RCSB PDB 2C4Q · PDBe 2C4Q · UniProt P03612
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