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Three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from mycobacterium tuberculosis

Analyse Three dimensional structure of bifunctional methylenetetrahydrofolate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2C2X
Type: protein
Length: 560 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methylenetetrahydrofolate dehydrogenase- methenyltetrahydrofolate cyclohydrolase
EC: 1.5.1.5, 3.5.4.9
UniProt: O50385
Pockets: 6 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Methylenetetrahydrofolate dehydrogenase- methenyltetrahydrofolate cyclohydrolase (EC 1.5.1.5, 3.5.4.9)	protein	280	43% helix, 19% strand	O50385

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	492	0.65	0.77	45	empty
2	429	0.65	0.78	41	empty
3	80	0.31	0.74	19	empty
4	56	0.30	0.76	20	empty
5	56	0.28	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 1643 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

2C2X · Three dimensional structure of bifunctional methylenetetrahydrofolate… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt O50385
Elsewhere: RCSB PDB 2C2X · PDBe 2C2X · UniProt O50385

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