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The crystal structure of a CYS25ALA mutant of human procathepsin S

Analyse The crystal structure of a CYS25ALA mutant of human procathepsin S in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2C0Y
Type: protein
Length: 308 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Procathepsin S
EC: 3.4.22.27
UniProt: P25774
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Procathepsin S (EC 3.4.22.27)	protein	308	37% helix, 19% strand	P25774

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.50	0.80	23	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

2C0Y · The crystal structure of a CYS25ALA mutant of human procathepsin S · the same entry in another collection · chain A against A, TM-score 1.00
P25774 · AlphaFold monomer V2.0 prediction for cathepsin S (P25774) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25774
Elsewhere: RCSB PDB 2C0Y · PDBe 2C0Y · UniProt P25774

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