Research workbench
Crystal structure of ACCD5 (RV3280), an acyl-CoA carboxylase beta-subunit from mycobacterium tuberculosis
Analyse Crystal structure of ACCD5 (RV3280), an acyl-CoA carboxylase beta-subunit from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BZR
- Type
- protein
- Length
- 3,041 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Propionyl-CoA carboxylase beta chain 5
- EC
- 6.4.1.3
- UniProt
- P96885
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 5 distinct chains · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Propionyl-CoA carboxylase beta chain 5 (EC 6.4.1.3) | protein | 512 | 43% helix, 18% strand | P96885 |
| B | Propionyl-CoA carboxylase beta chain 5 (EC 6.4.1.3) | protein | 504 | 43% helix, 18% strand | P96885 |
| C, E | Propionyl-CoA carboxylase beta chain 5 (EC 6.4.1.3) | protein | 506 | 43% helix, 19% strand | P96885 |
| D | Propionyl-CoA carboxylase beta chain 5 (EC 6.4.1.3) | protein | 508 | 43% helix, 19% strand | P96885 |
| F | Propionyl-CoA carboxylase beta chain 5 (EC 6.4.1.3) | protein | 505 | 44% helix, 18% strand | P96885 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 916 | 0.80 | 0.82 | 93 | empty |
| 2 | 754 | 0.79 | 0.83 | 69 | empty |
| 3 | 760 | 0.78 | 0.82 | 65 | empty |
| 4 | 1162 | 0.77 | 0.79 | 121 | empty |
| 5 | 736 | 0.74 | 0.79 | 104 | empty |
Interfaces
12 interfaces between chains.
- B–E · 4722 Ų buried · 60 hydrogen bonds · protein-protein
- A–D · 4709 Ų buried · 61 hydrogen bonds · protein-protein
- C–F · 4689 Ų buried · 60 hydrogen bonds · protein-protein
- E–F · 1543 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 1497 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 2BZR · Crystal structure of accD5 (Rv3280), an acyl-CoA carboxylase beta- subunit from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P96885
- Elsewhere: RCSB PDB 2BZR · PDBe 2BZR · UniProt P96885
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