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The crystal structure of the complex between the uba and ubl domains of DSK2
Analyse The crystal structure of the complex between the uba and ubl domains of DSK2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BWE
- Type
- protein
- Length
- 1,047 residues
- Chains
- 21
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DSK2
- UniProt
- P48510
- Pockets
- 9 · best druggability 0.55
Structure
x-ray diffraction · 9 distinct chains · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, G, J, L, N, O, R | DSK2 | protein | 46 | 67% helix, 0% strand | P48510 |
| B | DSK2 | protein | 48 | 65% helix, 0% strand | P48510 |
| C | DSK2 | protein | 48 | 65% helix, 0% strand | P48510 |
| D, Q | DSK2 | protein | 47 | 66% helix, 0% strand | P48510 |
| F, H, I, M | DSK2 | protein | 45 | 67% helix, 0% strand | P48510 |
| K | DSK2 | protein | 47 | 66% helix, 0% strand | P48510 |
| P | DSK2 | protein | 44 | 68% helix, 0% strand | P48510 |
| S, T | DSK2 | protein | 73 | 22% helix, 40% strand | P48510 |
| U | DSK2 | protein | 72 | 22% helix, 38% strand | P48510 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 290 | 0.55 | 0.76 | 39 | empty |
| 2 | 332 | 0.53 | 0.74 | 32 | empty |
| 3 | 242 | 0.51 | 0.76 | 35 | empty |
| 4 | 145 | 0.47 | 0.77 | 20 | empty |
| 5 | 124 | 0.42 | 0.76 | 20 | empty |
Interfaces
31 interfaces between chains.
- C–D · 586 Ų buried · 4 hydrogen bonds · protein-protein
- E–F · 584 Ų buried · 6 hydrogen bonds · protein-protein
- Q–R · 583 Ų buried · 10 hydrogen bonds · protein-protein
- N–O · 583 Ų buried · 7 hydrogen bonds · protein-protein
- G–H · 582 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2BWE · The crystal structure of the complex between the UBA and UBL domains of Dsk2 · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48510
- Elsewhere: RCSB PDB 2BWE · PDBe 2BWE · UniProt P48510
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