Research workbench
Three-dimensional structure of the hermes DNA transposase
Analyse Three-dimensional structure of the hermes DNA transposase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BW3
- Type
- protein
- Length
- 602 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transposase
- UniProt
- Q25442
- Pockets
- 7 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transposase | protein | 518 | 61% helix, 8% strand | Q25442 |
| B | Transposase | protein | 84 | 68% helix, 2% strand | Q25442 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.53 | 0.79 | 28 | empty |
| 2 | 66 | 0.52 | 0.86 | 21 | empty |
| 3 | 194 | 0.47 | 0.75 | 33 | empty |
| 4 | 187 | 0.45 | 0.74 | 29 | empty |
| 5 | 56 | 0.38 | 0.80 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 3679 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 modified (engineered).
Compared structures
- 2BW3 · Three-dimensional structure of the Hermes DNA transposase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q25442
- Elsewhere: RCSB PDB 2BW3 · PDBe 2BW3 · UniProt Q25442
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