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Crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Analyse Crystal structures of human pyruvate dehydrogenase kinase 2 containing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2BTZ
Type: protein
Length: 357 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pyruvate dehydrogenase kinase isoenzyme 2
EC: 2.7.1.99
UniProt: Q15119
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pyruvate dehydrogenase kinase isoenzyme 2 (EC 2.7.1.99)	protein	357	53% helix, 14% strand	Q15119

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.69	0.96	13	empty
2	121	0.65	0.88	20	empty
3	176	0.53	0.79	28	empty

Compared structures

2BTZ · crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and… · the same entry in another collection · chain A against A, TM-score 1.00
Q15119 · AlphaFold monomer V2.0 prediction for [pyruvate dehydrogenase (acetyl-transferring)]… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15119
Elsewhere: RCSB PDB 2BTZ · PDBe 2BTZ · UniProt Q15119

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