Research workbench
3-isopropylmalate dehydrogenase from escherichia COLI
Analyse 3-isopropylmalate dehydrogenase from escherichia COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CM7
- Type
- protein
- Length
- 726 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (3-isopropylmalate dehydrogenase)
- UniProt
- P30125
- Pockets
- 7 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Protein (3-isopropylmalate dehydrogenase) | protein | 363 | 44% helix, 21% strand | P30125 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 546 | 0.62 | 0.74 | 61 | empty |
| 2 | 124 | 0.60 | 0.85 | 27 | empty |
| 3 | 119 | 0.59 | 0.85 | 24 | empty |
| 4 | 306 | 0.52 | 0.74 | 34 | empty |
| 5 | 104 | 0.41 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 2363 Ų buried · 53 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30125
- Elsewhere: RCSB PDB 1CM7 · PDBe 1CM7 · UniProt P30125
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