Research workbench
Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B2705
Analyse Crystal structures and KIR3DL1 recognition of three immunodominant viral… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BST
- Type
- protein
- Length
- 385 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-27 alpha chain precursor; Beta-2-microglobulin…
- UniProt
- P03989, P61769, Q8B2U6
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-27 alpha chain precursor | protein | 276 | 26% helix, 39% strand | P03989 |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| C | Influenza nucleoprotein | protein | 9 | 0% helix, 0% strand | Q8B2U6 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.71 | 0.94 | 23 | empty |
| 2 | 640 | 0.70 | 0.78 | 59 | empty |
| 3 | 134 | 0.50 | 0.80 | 22 | empty |
| 4 | 117 | 0.48 | 0.80 | 24 | empty |
| 5 | 59 | 0.36 | 0.79 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1376 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 991 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2BST · Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides… · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03989
- Every structure of UniProt P61769
- Every structure of UniProt Q8B2U6
- Elsewhere: RCSB PDB 2BST · PDBe 2BST · UniProt P03989 · UniProt P61769 · UniProt Q8B2U6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.